Table 4.
Associations of weighted genetic risk score (GRS) based on the 11 SNPs with risk of gestational diabetes (GDM) stratified by family history of type 2 diabetes, age, smoking status, and BMI at baseline among 8722 women from Nurses’ Health Study II (NHSII) (total N=7538, GDM cases N=2060) and the Danish National Birth Cohort (DNBC) (total N=1184, GDM cases N=576).
| Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | Per allele increase | p for interaction | |
|---|---|---|---|---|---|---|
| Family history of T2D | ||||||
| Yes | 1.00 | 1.01 (0.76, 1.34) | 0.98 (0.74, 1.30) | 1.25 (0.95, 1.64) | 1.01 (0.99, 1.03) | |
| No | 1.00 | 1.10 (0.94, 1.29) | 1.33 (1.14, 1.56) | 1.64 (1.41, 1.92) | 1.04 (1.03, 1.06) | 0.15 |
| Age at baseline | ||||||
| <35 years | 1.00 | 1.07 (0.89, 1.28) | 1.17 (0.98, 1.39) | 1.46 (1.23, 1.74) | 1.03 (1.02, 1.04) | |
| ≥35 years | 1.00 | 1.06 (0.86, 1.31) | 1.32 (1.07, 1.62) | 1.62 (1.32, 1.98) | 1.04 (1.03, 1.06) | 0.93 |
| Smoking | ||||||
| No | 1.00 | 1.03 (0.87, 1.22) | 1.29 (1.09, 1.52) | 1.54 (1.31, 1.81) | 1.04 (1.03, 1.06) | |
| Yes | 1.00 | 1.12 (0.89, 1.41) | 1.11 (0.88, 1.40) | 1.48 (1.18, 1.87) | 1.02 (1.00, 1.04) | 0.56 |
| BMI | ||||||
| BMI ≥25 kg/m2 | 1.00 | 0.95 (0.76, 1.21) | 1.20 (0.95, 1.51) | 1.56 (1.24, 1.97) | 1.03 (1.02, 1.05) | |
| BMI <25 kg/m2 | 1.00 | 1.09 (0.92, 1.30) | 1.26 (1.06, 1.49) | 1.49 (1.26, 1.76) | 1.04 (1.02, 1.05) | 0.81 |