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. Author manuscript; available in PMC: 2019 Aug 20.
Published in final edited form as: Curr Top Dev Biol. 2018 Mar 31;130:143–191. doi: 10.1016/bs.ctdb.2018.02.005

Figure 3. The BM of embryonic mouse tooth bud.

Figure 3.

(A) The basement membrane underlies the oral epithelium and surrounds inner and outer enamel epithelia of the enamel organ. The dental papilla lies beneath the inner enamel epithelium and gives rise to the dentin and pulp. (B) Laminin γ1 and nidogen-2 are expressed around the tooth bud. (C) FRAS1 and FREM1 show a spatially specific expression pattern along the inner enamel epithelium. (D) A gradient expression pattern of netrin-1 is found subjacent to the primary enamel knot.