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. Author manuscript; available in PMC: 2019 Aug 20.
Published in final edited form as: Nanomedicine (Lond). 2018 Dec 21;14(6):727–752. doi: 10.2217/nnm-2018-0436

Figure 6. Western blotting analysis of markers involved in apoptosis.

Figure 6

(A) Expression of p53 and its downstream proteins (MDM2 and p21) was analyzed on U-87 MG cells after 72 h of treatment with 100 μg ml-1 of Mag-SLNs, 1.33 μM of nutlin-3a, or 100 μg ml-1 of Nut-Mag-SLNs (corresponding to 1.33 μM of drug), and compared with control cultures. (B) Quantitative evaluation of western blotting results.

*p < 0.01.

MDM2: Murine double minute; Mag-SLNs: Magnetic solid lipid nanoparticles; Nut-Mag-SNLs: Nutlin-loaded magnetic solid lipid nanoparticles.