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. Author manuscript; available in PMC: 2019 Aug 20.
Published in final edited form as: Nanomedicine (Lond). 2018 Dec 21;14(6):727–752. doi: 10.2217/nnm-2018-0436

Figure 8. Nutlin-loaded magnetic solid lipid nanoparticles crossing of the in vitro blood–brain barrier model.

Figure 8

(A) Metabolic WST-1 assay on BBB model (600 μg ml-1) and on U-87 MG cells (200 μg ml-1) after treatment with Mag-SLNs and Nut-Mag-SLNs. (B, C) Flow cytometry evaluation of FITC-Nut-Mag-SLN uptake by bEnd.3 and U-87 MG cells at different time points.

*p < 0.05.

BBB: Blood–brain barrier; Mag-SLNs: Magnetic solid lipid nanoparticles; Nut-Mag-SNLs: Nutlin-loaded magnetic solid lipid nanoparticles.