Table 1.

Impact of Estrogen Receptor-Alpha or -Beta Antagonism on Insulin-Induced Hypoglycemia in Male versus Female Rats

	Plasma Glucose Levels (mg/dL)
	Vehicle sca	Insulin sc
	Vehicle icvb	Vehicle icv	MPPc icv	PHTPPd icv
	V/V e	V/INSf	MPP/INS	PHTPP/INS
Male	126.6 ± 5.5	71.4 ± 3.8g	73.5 ± 3.2g	66.5 ± 4.1g
Female	157.4 ± 3.8	69.2 ± 3.6g	64.8 ± 3.4g	63.5 ± 3.6g

^asubcutaneous

^bintracerebroventricular

^c1,3-Bis(4-hydroxyphenyl)-4-methyl-5-[4-(2-piperidinylethoxy)phenol]-1H-pyrazole dihydrochloride

^d4-[2-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol

^en=6 animals per group

^finsulin

^gp<0.001 versus V/V; data were analyzed by two-way ANOVA for sex versus treatment.