Table 3.

Summary of Effects of Insulin-Induced Hypoglycemia (IIH) on Ventromedial Hypothalamic Nucleus GABAergic Neuron Adrenergic Receptor (AR), Estrogen Receptor (ER), and Pyruvate Recycling Enzyme Protein Expression in Male versus Female Rats: Role of ER-Alpha and ER-Beta

	MALE				FEMALE
	Vehicle sca	Insulin sc			Vehicle sc	Insulin sc
	Vehicle icv b	Vehicle icv	MPPc icv	PHTPPd icv	Vehicle icv	Vehicle icv	MPP icv	PHTPP icv
	V/V n=6	V/INSe n=6	MPP/INS n=6	PHTPP/INS n=6	V/V n=6	V/INS n=6	MPP/INS n=6	PHTPP/INS n=6
Alpha1-AR		↓f vs V/V	↑ vs V/INS Ng	N.C.h vs V/INS		N.C. vs V/V	↑ vs V/INS	N.C. vs V/INS
Alpha2-AR		N.C. vs V/V	N.C. vs V/INS	N.C. vs V/INS		↓ vs V/V	↑ vs V/INS N	↑ vs V/INS N
Beta1-AR		↓ vs V/V	↑ vs V/INS N	N.C. vs V/INS		↓ vs V/V	N.C. vs V/INS	N.C. vs V/INS
ER-alpha		↓ vs V/V	↑ vs V/INS N	N.C. V/INS	↓ vs. Male V/V	↑ vs V/V	↓ vs V/INS N	↓ vs V/INS N
ER-beta		↑ vs V/V	↓ vs V/INS N	↓ vs V/INS N		↑ vs V/V	↓ vs V/INS N	↓ vs V/INS N
GPERi		N.C. vs V/V	N.C. vs V/INS	↓ vs V/INS		N.C. vs V/V	↑ vs V/INS	N.C. vs V/INS
MCT2j		N.C. vs V/V	N.C. vs V/INS	↑ vs V/INS		↑ vs V/V	N.C. vs V/INS	↑ vs V/INS
GLSk		↓ vs V/V	↑ vs V/INS N	N.C. vs V/INS N		↓ vs V/V	N.C. vs V/INS	↑ vs V/INS N
ME-1l		↑ vs V/V	N.C. vs V/INS	↓ vs V/INS N		N.C. V/INS	N.C. vs V/INS	↑ vs V/INS

^asubcutaneous

^bintracerebroventricular

^c1,3-Bis(4-hydroxyphenyl)-4-methyl-5-[4-(2-piperidinylethoxy)phenol]-1H-pyrazole dihydrochloride

^d4-[2-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol

^einsulin

^farrows indicate a significant difference of at least p<0.05

^gN normalized relative to V/V

^hno change

ⁱG protein-coupled estrogen receptor-1

^jmonocarboxylate transporter-2

^kglutaminase

^lmalic enzyme-1