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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Biochem Pharmacol. 2019 May 8;167:3–12. doi: 10.1016/j.bcp.2019.05.006

Figure 3. Structures of the RNF146-iso-ADPr complex and ankyrin repeat clusters (ARCs) of PARP5a binding to Tankyrase binding motif (TBM) of RNF146.

Figure 3

(A) Cartoon model of the RNF146- iso-ADPr complex highlighting the RING finger and WWE domain (PDB ID: 4QPL), with a close-up of the RNF146-iso-ADPr binding interface. (B) Cartoon model of the complex between RNF146 TBM and PARP5a (PDB ID: 6CF6), with a close-up of the TBM binding interface at an ARC of PARP5a. Structures were generated via Protein Data Bank and PyMOL.