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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Biochem Pharmacol. 2019 May 8;167:3–12. doi: 10.1016/j.bcp.2019.05.006

Figure 6. Working models of PARdU.

Figure 6

(A) PARP5a/b binds its substrate via Tankyrase Binding Motif (TBM) before RNF146 binds the iso-ADPr within PAR (pink dashed line) through its WWE domain and becomes catalytically active and poly-ubiquitinates the substrate to tag it for proteasomal degradation. (B) PARPs synthesize PAR, which is then bound by PAR-binding proteins. RNF146 binds PAR, becomes catalytically active, and ubiquitinates proximal PAR-binding proteins.