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A summary of PARdU substrates, their associated biological processes and possible pathological outcomes upon PARdU dysregulation.
| PARdU substrate | Biological Pathway | Pathology |
|---|---|---|
| Axin1/2 | Wnt signaling | Cancer |
| 3BP2 | SRC, SYK, VAV signaling | Cherubism |
| PTEN | AKT signaling; tumor suppressor | Cancer |
| AMOTL2 | Tight junctions | Cancer |
| PARP1 | DNA damage, stress response | Cancer |
