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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Expert Rev Proteomics. 2019 Jul 25;16(8):665–680. doi: 10.1080/14789450.2019.1645604

Figure 5:

Figure 5:

Linking Histopathology with MALDI IMS Glycan Images. a) H&E stain of an invasive ductal carcinoma at 2X magnification with pathologist annotation of tumor (red), stroma (green), and necrotic (blue) regions. b) Distribution of Hex8HexNAc2 + 1Na (m/z 1743.5956) showing strong correlation with the tumor region of the tissue. c) Distribution of Hex5dHex1HexNAc2 + 1Na (m/z 1809.6838) throughout stroma region of the tissue. d) Distribution of Hex5HexNAc4NeuAc1 + 1Na throughout necrotic and stromal region of the tissue. Additionally, other glycan structures seen correlating with each region in b-d are shown below the respective image. Images were created using SCiLS Lab 2017a and previously described in Scott et. al. 2018.