Table 1.
The effect of 5F02, olaparib, and enzalutamide on the viability of LNCaP expressing both wild-type and constitutively active AR splice variant AR-V7. Cell viability was examined using the CellTiter Blue assay. The effective doses (ED) were calculated using XLfit software.
5F02 | Olaparib | Enzalutamide | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
ED90 μM | ED70 μM | ED50 μM | ED20 μM | ED90 μM | ED70 μM | ED50 μM | ED20 μM | ED90 μM | ED70 μM | ED50 μM | ED20 μM |
15.7 | 8.9 | 6.3 | 3.5 | 1835 | 228.7 | 61.9 | 7.3 | 4751.7 | 163.7 | 19.8 | 0.6 |