. Author manuscript; available in PMC: 2019 Dec 18.

Published in final edited form as: Pediatr Res. 2019 Jun 18;86(3):365–374. doi: 10.1038/s41390-019-0461-1

Table 2.

Comparison of diffusion parameters in white matter regions between FT, VPT, and BI infants

Parameter	Region^a	Estimated marginal mean (95% confidence intervals) ^b			VPT v. BI^c
Parameter	Region^a	FT (n = 55)	VPT (n = 69)	BI (n = 32)	VPT v. BI^c
FA	L ALIC^***	0.33 (.31–.35)	0.28 (.27–.30)^***	0.27 (.24–.29)^***
	R ALIC^**	0.34 (.32–.36)	0.30 (.28–.31)^*	0.27 (.25–.30) ^**
	L PLIC^***	0.47 (.46–.49)	0.46 (.45–.47)	0.43 (.41–.45)^**	^*
	R PLIC ^***	0.48 (.46–.50)	0.46 (.46–.47)	0.42 (.40–.44)^**	^**
	L OPRA	0.32 (.30–.34)	0.31 (.30–.33)	0.30 (.28–.32)
	R OPRA	0.32 (.30–.33)	0.32 (.31–.33)	0.31 (.29–.33)
	L CNBD^**	0.31 (.30–.33)	0.30 (.30–.31)	0.28 (,26–.29)^*	^*
	R CNBD ^***	0.30 (.28–.31)	0.30 (.29–.30)	0.26 (.24–.28)^*	^***
	L CSOV ^***	0.23 (.21–.24)	0.15 (.14–.17)^***	0.16 (.14–.18)^***
	R CSOV^***	0.21 (.20–.23)	0.15 (.14–.16)^***	0.17 (.15–.19)^**
	L FRNT	0.14 (.13–.16)	0.14 (.13–.14)	0.12 (.11–.14)
	R FRNT	0.14 (.13–.16)	0.13 (.13–.14)	0.13 (.11–.14)
	CC ^***	0.51 (.48–.54)	0.44 (.42–.46)^**	0.36 (.32–.40)^***	^***
MD	L ALIC	1.37 (1.34–1.40)	1.37 (1.35–1.39)	1.38 (1.34–1.41)
	R ALIC	1.37 (1.35–1.40)	1.36 (1.35–1.38)	1.35 (1.32–1.39)
	L PLIC	1.25 (1.23–1.28)	1.22 (1.20–1.24)	1.23 (1.21–1.26)
	R PLIC ^*	1.23 (1.21–1.26)	1.20 (1.19–1.22)	1.23 (1.21–1.26)
	L OPRA^**	1.50 (1.45–1.54)	1.57 (1.53–1.60)	1.65 (1.59–1.70)^**	^*
	R OPRA^**	1.50 (1.45–1.54)	1.54 (1.51–1.57)	1.62 (1.57–1.67)^**	^**
	L CNBD^*	1.42 (1.39–1.45)	1.45 (1.43–1.47)	1.49 (1.46–1.53)^*	^*
	R CNBD ^**	1.42 (1.39–1.44)	1.46 (1.44–1.48)	1.51 (1.48–1.55)^***	^*
	L CSOV^***	1.44 (1.39–1.49)	1.70 (1.67–1.74)^***	1.61 (1.55–1.68) ^***	^*
	R CSOV^***	1.43 (1.38–1.48)	1.71 (1.67–1.74)^***	1.61 (1.55–1.67)^***	^**
	L FRNT	1.66 (1.62–1.71)	1.69 (1.66–1.73)	1.71 (1.66–1.76)
	R FRNT	1.67 (1.62–1.72)	1.70 (1.67–1.74)	1.71 (1.65–1.76)
	CC	1.60 (1.49–1.71)	1.69 (1.62–1.77)	1.79 (1.65–1.93)

Note. Models adjusted for post-menstrual age at scan, medical risk propensity score and race. General linear models performed with embedded Bonferroni correction. ALIC, anterior limb of the internal capsule; PLIC, posterior limb of the internal capsule; OPRA, optic radiations; CNBD, cingulum; CSOV, centrum semiovale; FRNT, frontal lobe; CC, corpus callosum. L, left; R, right.

F statistic in analysis of variance,

pairwise comparisons with FT infants;

pairwise comparisons between VPT and BI infants.

p ≤ 0.05;

^**

p ≤ 0.01;

^***

p ≤ 0.001