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. Author manuscript; available in PMC: 2019 Oct 31.
Published in final edited form as: ACS Appl Mater Interfaces. 2018 Oct 19;10(43):36786–36795. doi: 10.1021/acsami.8b15368

Figure 3.

Figure 3.

Effects of HIFU parameters on the damaged area and ablation area fraction. a) Damaged area and ablation area fraction in the RBC phantoms containing PL-hMSN at different concentrations after HIFU treatment for 30 s at a pulse duration of 16.8 μs, a pulse repetition frequency of 10 Hz (duty cycle of 0.017%), and peak negative pressure of 16.8 MPa. b) Damaged area and ablation area fraction in the RBC phantoms containing PL-hMSN (200 μg mL−1) after HIFU treatment at the different peak negative pressures for 30 s at a pulse duration of 16.8 μs and a pulse repetition frequency of 10 Hz (duty cycle of 0.017%). c) Damaged areas and ablation area fraction in the RBC phantoms containing PL-hMSN (200 μg mL−1) after HIFU treatment at different pulse durations for 30 s at a peak negative pressure of 16.8 MPa and a pulse repetition frequency of 10 Hz. d) Damaged area and ablation area fraction in the RBC phantoms containing PL-hMSN (200 μg mL−1) after HIFU treatment for different durations at a peak negative pressure of 16.8 MPa, a pulse duration of 16.8 μs, and a pulse repetition frequency of 10 Hz (duty cycle of 0.017%). Error bars = 1 SD, studies were run in triplicate.