Figure 2.

Burstiness for a single gene. (a) A phase diagram shows the burst significance as a function of model parameters. A nonbursty regime is indicated by ξ = 0 (black), whereas ξ > 0 indicates a bursty regime (yellow-red). The dashed green line is the boundary predicted via mean field (see Supporting Materials and Methods, Section SI). (b) Non-Gaussian parameters of the distribution of the supercoiling at the promoter ${\sigma }_p$ as a function of ξ, for different values of $\overline{J}/D$ and k_topo/k₀ are shown. The kurtosis (skewness) is correlated (anticorrelated) with ξ. To see this figure in color, go online.