Table 2.

Association of the 14 identified metabolic biomarkers with all-cause mortality in the fully adjusted model

Biomarker	Full name	HR	95% CI	P	I 2	P (het)
XXL-VLDL-L	Total lipids in chylomicrons and extremely large VLDL	0.80	0.75–0.85	1.53 × 10−13	0.08	0.363
S-HDL-L	Total lipids in small HDL	0.87	0.84–0.90	5.98 × 10−19	0.52	0.018
VLDL-D	Mean diameter for VLDL particles	0.85	0.80–0.90	8.51 × 10−8	0.21	0.241
PUFA/FA	Ratio of polyunsaturated fatty acids to total fatty acids (%)	0.78	0.75–0.80	1.06 × 10−47	0.71	8.65 × 10−5
Glc	Glucose	1.16	1.13–1.19	2.22 × 10−29	0.56	0.008
Lac	Lactate	1.06	1.03–1.10	6.24 × 10−5	0.28	0.173
His	Histidine	0.93	0.90–0.96	1.15 × 10−5	0.24	0.213
Ile	Isoleucine	1.23	1.14–1.32	2.14 × 10−8	0.39	0.078
Leu	Leucine	0.82	0.76–0.89	7.34 × 10−7	0.35	0.109
Val	Valine	0.87	0.82–0.92	1.04 × 10−6	0.07	0.376
Phe	Phenylalanine	1.13	1.09–1.17	2.39 × 10−12	0.44	0.052
AcAce	Acetoacetate	1.08	1.05–1.11	1.73 × 10−8	0.35	0.108
Alb	Albumin	0.89	0.87–0.92	9.96 × 10−13	0.52	0.017
GlycA	Glycoprotein acetyls	1.32	1.27–1.38	7.45 × 10−41	0.45	0.046

HR hazard ratio, CI conference interval, P P value, I² heterogeneity statistic, het heterogeneity, VLDL very low-density lipoprotein particle, HDL high-density lipoprotein. The statistics in this Table have been generated with the R-package meta using the survival analyses results from the individual cohorts as input