Table 3.
Association of the 14 identified metabolic biomarkers with all-cause and cause-specific mortality in the FINRISK 1997 cohort
| Biomarker | N | All-cause (HR, 95% CI, P) | Cancer (HR, 95% CI, P) | Cardiovascular (HR, 95% CI, P) | Nonlocalized infections (HR, 95% CI, P) | Other (HR, 95% CI, P) |
|---|---|---|---|---|---|---|
| XXL-VLDL-L | 7583 | 0.77, 0.68–0.86, 1.00 × 10−5 | 0.78, 0.64–0.95, 0.016 | 0.85, 0.73–0.99, 0.039 | 0.47, 0.26–0.86, 0.014 | 0.57, 0.40–0.82, 0.002 |
| S-HDL-L | 7583 | 0.95, 0.89–1.01, 0.085 | 0.89, 0.80–0.98, 0.023 | 0.96, 0.88–1.04, 0.319 | 0.80, 0.60–1.07, 0.130 | 1.00, 0.85–1.19, 0.966 |
| VLDL-D | 7583 | 0.99, 0.88–1.11, 0.802 | 0.95, 0.78–1.16, 0.619 | 1.06, 0.91–1.24, 0.462 | 1.89, 1.01–3.54, 0.045 | 0.90, 0.66–1.23, 0.520 |
| PUFA/FA | 7583 | 0.73, 0.69–0.78, <2.22 × 10−16 | 0.74, 0.66–0.83, 2.31 × 10−7 | 0.77, 0.70–0.84, 2.77 × 10−9 | 0.50, 0.37–0.68, 9.01 × 10−6 | 0.69, 0.58–0.82, 4.06 × 10−5 |
| Glc | 7583 | 1.13, 1.09–1.18, 5.85 × 10−9 | 1.05, 0.96–1.13, 0.273 | 1.16, 1.10–1.22, 1.29 × 10−8 | 1.05, 0.85–1.29, 0.643 | 1.03, 0.88–1.20, 0.721 |
| Lac | 7583 | 1.07, 1.00–1.14, 0.038 | 1.02, 0.92–1.14, 0.694 | 1.14, 1.05–1.23, 0.003 | 1.08, 0.77–1.52, 0.656 | 0.97, 0.83–1.14, 0.727 |
| His | 7583 | 0.93, 0.86–0.99, 0.031 | 0.88, 0.78–0.98, 0.023 | 0.89, 0.81–0.97, 0.010 | 1.12, 0.78–1.62, 0.538 | 1.11, 0.93–1.31, 0.250 |
| Ile | 7583 | 1.12, 0.95–1.32, 0.180 | 1.07, 0.81–1.41, 0.638 | 1.05, 0.84–1.32, 0.661 | 0.57, 0.24–1.38, 0.214 | 1.26, 0.84–1.88, 0.270 |
| Leu | 7583 | 0.80, 0.67–0.97, 0.020 | 0.89, 0.65–1.22, 0.474 | 0.73, 0.57–0.94, 0.016 | 1.02, 0.40–2.62, 0.967 | 0.83, 0.53–1.30, 0.419 |
| Val | 7583 | 0.89, 0.79–1.02, 0.084 | 0.95, 0.77–1.19, 0.672 | 1.05, 0.88–1.26, 0.580 | 1.32, 0.67–2.61, 0.425 | 0.64, 0.48–0.86, 0.003 |
| Phe | 7583 | 1.21, 1.10–1.33, 4.17 × 10−5 | 1.14, 0.98–1.33, 0.087 | 1.28, 1.13–1.44, 7.61 × 10−5 | 1.21, 0.75–1.96, 0.437 | 1.07, 0.84–1.36, 0.575 |
| AcAce | 7583 | 1.06, 1.00–1.13, 0.038 | 1.04, 0.94–1.15, 0.441 | 1.07, 0.99–1.15, 0.096 | 1.23, 0.90–1.69, 0.191 | 1.11, 0.96–1.28, 0.167 |
| Alb | 7583 | 0.89, 0.83–0.96, 0.003 | 0.90, 0.79–1.01, 0.084 | 0.88, 0.79–0.97, 0.009 | 0.81, 0.55–1.17, 0.261 | 1.00, 0.83–1.21, 0.997 |
| GlycA | 7583 | 1.41, 1.26–1.57, 5.75 × 10−10 | 1.35, 1.12–1.61, 0.001 | 1.36, 1.18–1.57, 3.13 × 10−5 | 2.03, 1.15–3.59, 0.015 | 1.52, 1.16–2.01, 0.003 |
The number of (cause-specific) deaths were 1210 (all-cause), 434 (cancer), 687 (cardiovascular), 43 (nonlocalized infections), and 189 (other). N number of samples, HR hazard ratio, CI conference interval, P P value. The statistics in this Table have been generated with the R-package survival