Table 4.

Results of the discrimination and reclassification analyses for all-cause mortality in the FINRISK 1997 cohort comparing the conventional risk factor score with the metabolic biomarker score

Follow-up time (years)	Age	Conventional risk factor score C-statistic	Metabolic biomarker score C-statistic	Difference in C-statistic	IDI
5	All	0.772	0.837	0.065 ± 0.019, P = 5.48 × 10−4	5.9 ± 1.9%, P = 0.001
5	>60	0.626	0.732	0.105 ± 0.027, P = 0.0001	8.6 ± 2.1%, P = 3.20 × 10−5
10	All	0.790	0.830	0.040 ± 0.010, P = 2.48 × 10−5	8.6 ± 1.2%, P = 1.83 × 10−12
10	>60	0.650	0.715	0.065 ± 0.014, P = 3.29 × 10−6	11.9 ± 1.5%, P = 1.13 × 10−14

The estimates for the risk scores were derived from the Estonian Biobank cohort. The conventional risk factor score, included sex, body mass index, systolic blood pressure, total cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides, creatinine, smoking status, alcohol consumption, and prevalent diabetes, cardiovascular disease, and cancer. The metabolic biomarker score, included total lipids in extremely large very low-density lipoprotein particle (VLDL), total lipids in small HDL, VLDL diameter, ratio of polyunsaturated fatty acids to total fatty acids, glucose, lactate, histidine, isoleucine, leucine, valine, phenylalanine, acetoacetate, albumin, glycoprotein acetyls, and sex. IDI integrated discrimination improvement. The statistics in this Table have been generated with custom-made functions in R