Table 4.
Follow-up time (years) | Age | Conventional risk factor score C-statistic | Metabolic biomarker score C-statistic | Difference in C-statistic | IDI |
---|---|---|---|---|---|
5 | All | 0.772 | 0.837 | 0.065 ± 0.019, P = 5.48 × 10−4 | 5.9 ± 1.9%, P = 0.001 |
5 | >60 | 0.626 | 0.732 | 0.105 ± 0.027, P = 0.0001 | 8.6 ± 2.1%, P = 3.20 × 10−5 |
10 | All | 0.790 | 0.830 | 0.040 ± 0.010, P = 2.48 × 10−5 | 8.6 ± 1.2%, P = 1.83 × 10−12 |
10 | >60 | 0.650 | 0.715 | 0.065 ± 0.014, P = 3.29 × 10−6 | 11.9 ± 1.5%, P = 1.13 × 10−14 |
The estimates for the risk scores were derived from the Estonian Biobank cohort. The conventional risk factor score, included sex, body mass index, systolic blood pressure, total cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides, creatinine, smoking status, alcohol consumption, and prevalent diabetes, cardiovascular disease, and cancer. The metabolic biomarker score, included total lipids in extremely large very low-density lipoprotein particle (VLDL), total lipids in small HDL, VLDL diameter, ratio of polyunsaturated fatty acids to total fatty acids, glucose, lactate, histidine, isoleucine, leucine, valine, phenylalanine, acetoacetate, albumin, glycoprotein acetyls, and sex. IDI integrated discrimination improvement. The statistics in this Table have been generated with custom-made functions in R