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. 2019 Aug 20;10(9):630. doi: 10.1038/s41419-019-1733-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Determination of the sensitizing effect and CI value of PPD and oxaliplatin by MTT assay. b Wound healing assay of PLC/PRF/5 and HepG2 cells treated with PPD, OXA, or a combination of PPD and OXA. Wound healing was observed 48 h after treatment. c Changes in the tumor volumes of the PLC/PRF/5 xenografts. Tumor growth was considerably suppressed in the combined treatment group compared with the tumor growths in the PPD and OXA groups. d Number of tumors that shifted to the lungs in different groups. PPD considerably inhibited lung metastasis. e Immunohistochemical staining for E-cadherin and vimentin in tumor samples from xenografts. Data are presented as means of three experiments, and error bars represent SD (*P < 0.05 and **P < 0.01)