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. 2019 Aug 20;10:3407. doi: 10.1038/s41467-019-11276-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Main molecular and clinical characteristics of lung neuroendocrine neoplasms. Upper panel: Radar charts of the expression level (z-score) of the characteristic genes [DLL3, ASCL1, ROBO1, SLIT1, ANGPTL3, ERBB4, UGT genes family, OTP, NKX2-1, PD-L1 (CD274), and other immune checkpoint genes] of each LNET molecular cluster (Carcinoid A1, Carcinoid A2, and B clusters), supra-ca, LCNEC, and SCLC. The coloured text lists relevant characteristics—additional molecular, histopathological, and clinical data—of each group. Lower panel: heatmap of the expression level (z-score) of the characteristic genes of each group from the left panel, expressed in z-scores. Data necessary to reproduce the figure are provided in the European Genome-phenome Archive