Table 1.
Clinical characteristics of patients according to the development of in-hospital hypotension.
| Variables | Total N = 308 (100%) | Development of in-hospital hypotension | ||
|---|---|---|---|---|
| No N = 247 (80.2%) | Yes N = 61 (19.8%) | P | ||
| Age (years) | 63 [55–71] | 62 [54–71] | 66 [56–73] | 0.09 |
| Male gender [n (%)] | 192 (62.34) | 155 (62.75) | 37 (60.66) | 0.76 |
| qSOFA score (point) | 0 [0–1] | 0 [0–1] | 1 [0–1] | <0.01* |
| Initial vital sign | ||||
| MBP (mmHg) | 85 [77–96] | 87 [78–98] | 78 [73–87] | <0.01* |
| Heart rate (bpm) | 96 [85–108] | 94 [83–106] | 105 [95–120] | <0.01* |
| Body temperature (°C) | 37.7 [36.9–38.7] | 37.6 [36.8–38.5] | 38.3 [37.1–39.2] | 0.01* |
| Radiology features | ||||
| Size of abscess (cm) | 5 [3.3–6.8] | 5 [3.3–6.8] | 5 [3.4–6.5] | 0.91 |
| Multiple lesions [n (%)] | 94 (30.5) | 74 (30) | 20 (32.8) | 0.67 |
| Bilobar involvement [n (%)] | 47 (15.3) | 35 (14.2) | 12 (19.7) | 0.29 |
| Treatment modality [n (%)] | 0.15 | |||
| Antibiotic only | 98 (31.8) | 81 (32.8) | 17 (27.9) | |
| Antibiotics + Percutaneous drainage | 204 (66.2) | 163 (66) | 41 (67.2) | |
| Antibiotics + Surgical treatment | 6 (2) | 3 (1.2) | 3 (4.9) | |
| Timing of treatment | ||||
| Door to antibiotic time (hour) | 3.98 [2.88–5.13] | 3.98 [2.83–5.2] | 3.93 [3.15–5.08] | 0.88 |
| Door to intervention time (hour) | 15.84 [4.97–38.24] | 15.72 [4.83–27.82] | 17.02 [5.3–80.65] | 0.12 |
| Comorbidity [n (%)] | ||||
| Hypertension | 120 (38.96) | 96 (38.87) | 24 (39.34) | 0.95 |
| Diabetes mellitus | 84 (27.27) | 67 (27.13) | 17 (27.87) | 0.91 |
| Chronic kidney disease | 7 (2.27) | 4 (1.62) | 3 (4.92) | 0.14 |
| Malignancy | 121 (39.29) | 92(37.25) | 29 (47.54) | 0.14 |
| Liver cirrhosis | 9 (2.92) | 5 (2.02) | 4 (6.56) | 0.08 |
| Cardiovascular disease | 29([9.42) | 22 (8.91) | 7(11.48) | 0.54 |
| Laboratory data | ||||
| WBC count (10^3/μL) | 11.11 [7.66–15.23] | 11.36 [8.32–15.06] | 8.96 [6.04–15.35] | 0.11 |
| Hemoglobin (g/dL) | 12.15 [10.7–13.4] | 12.2 [10.8–13.5] | 11.7 [10.5–13.2] | 0.37 |
| Platelet count (10^3/μL) | 178 [124–272] | 192 [136–301] | 132 [88–198] | <0.01* |
| Neutrophil ratio (%) | 85.4 [79.9–89.5] | 83.95 [79.05–88.2] | 89.5 [85.4–93] | <0.01* |
| Prothrombin ratio (%) | 80 [69–93] | 80 [70–95] | 79 [66–89] | 0.2 |
| Creatinine (mg/dL) | 0.85 [0.65–1.08] | 0.8 [0.63–1.01] | 1.02 [0.81–1.5] | <0.01* |
| Albumin (g/dL) | 3.2 [2.8–3.6] | 3.2 [2.8–3.6] | 2.9 [2.7–3.4] | 0.01* |
| ALT (IU/L) | 40 [25–74] | 38 [24–66] | 56 [27–96] | 0.02* |
| Total bilirubin (mg/dL) | 1.1 [0.7–1.7] | 0.9 [0.6–1.6] | 1.3 [1–2.4] | <0.01* |
| C reactive protein (mg/L) | 169 [95–234] | 165 [90–228] | 197 [134–266] | 0.02* |
| Lactate (mmol/L) | 1.75 [1.1–2.8] | 1.3 [1–2] | 2.6 [1.6–4.8] | <0.01* |
| Bacteremia [n (%)] | 111 (36) | 64 (25.9) | 47 (77.1) | <0.01* |
| DNIa | 0.9 [−0.29–1.61] | 0.74 [−0.69–1.44] | 1.79 [0.99–2.73] | <0.01* |
*P < 0.05, Data are expressed in median [IQR] and n (%), aVariable was logarithmically transformed before analyses.
Abbreviations: qSOFA, quick sequential organ failure assessment; MBP, mean blood pressure; WBC, white blood cell; AST, aspartate aminotransferase; ALT, alanine aminotransferase; DNI, delta neutrophil index.