Skip to main content
. 2019 Aug 14;10:1909. doi: 10.3389/fimmu.2019.01909

Figure 4.

Figure 4

Blimp-1-deficient mice had increased mortality in systemic candidiasis. (A) Schematic design for the infection of Ctrl, Cko, Ctrl × tiger, and Cko × tiger mice with 5 × 105 CFU of C. albicans by intravenous injection. (B) The survival rates of Ctrl and Cko mice were recorded (n = 5 mice per group). The differences in survival rates were analyzed by a log-rank (Mantel-Cox) test. (C) Three days after infection, the fungal burden in the kidneys of Ctrl and Cko mice was quantified, and the resulting data are shown as the log10 value (n = 4 mice per group). (D–F) The frequency (D,E) and numbers (F) of B10 cells in the Ctrl × tiger and Cko × tiger mice at day 3 post-infection. (G–I) The frequency (G,H) and numbers (I) of IL-10+ (GFP+) B10 cells in the Ctrl × tiger and Cko × tiger mice at day 3 post-infection. Splenocytes were stimulated with LPS for 5 h before cell surface staining (n = 3 mice per group in D–I). Results are from at least two independent experiments and were analyzed by using an unpaired Student's t-test. Data are the mean ± SEM. *p < 0.05, **p < 0.01, and ***p < 0.001.