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sAPPα promotes the transcription of Arc and Zif268 mRNA. RT-qPCR showed that sAPPα (1 nM) promotes an increase in the expression of Arc mRNA in primary cortical cells in culture at 60, 120 min (n = 5) and 240 min (n = 4) relative to no-drug controls (n = 9; mean ± SEM). No significant change was detected at 15 or 30 min, nor 24 h (n = 4), nor was there a significant change in the negative control gene SP2 (n = 4). One sample t-tests; ∗p ≤ 0.05, ∗∗p ≤ 0.01, ∗∗∗∗p ≤ 0.0001.
