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. 2019 Aug 14;13:861. doi: 10.3389/fnins.2019.00861

FIGURE 3.

FIGURE 3

Tetanus strength-dependent potentiation in freely behaving TG rats. To develop a conditioning protocol that would induce robust LTP in TG rats comparable to that found in WT littermates a range of HFS paradigms were applied: (A) a single set of 400 Hz trains at 50% of maximal EPSP amplitude (400 Hz); (B) a single strong set of 400 Hz trains at 75% of maximal EPSP amplitude (s400 Hz); (C) three strong sets of 400 Hz trains at 75% of maximal EPSP amplitude (3 × s400 Hz). Left-hand panels show LTP time course. Inserts show representative EPSP traces at the times indicated. Calibration bars: vertical, 1 mV; horizontal, 10 ms. The time point of HFS application is indicated by arrow, arrow head and three arrow heads, respectively. Summary bar charts of LTP (last 10 min post-HFS) are in right hand panel. The # symbol stands for a statistical comparison between pre- and 3 h post-HFS values within one group (paired t-test) whereas an “ns” above the line indicates a comparison of 3 h post-HFS values between groups (unpaired t-test). One symbol, p < 0.05; two symbols, p < 0.01; four symbols, p < 0.0001; ns, p > 0.05. Values are mean ± S.E.M.% pre-HFS baseline EPSP amplitude.