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. 2019 Aug 14;13:861. doi: 10.3389/fnins.2019.00861

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Copyright © 2019 Qi, Klyubin, Hu, Ondrejcak and Rowan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Age-dependent deficit in depotentiation in anaesthetized TG rats. (A) Application of 1 Hz LFS (solid bar) following LTP induction by a sequence of s200 Hz HFS (arrow) and 3 × s400 Hz HFS (three arrow heads) failed to induce persistent depotentiation in 4–6-month-old TG rats, unlike their WT littermates, under urethane anaesthesia. In contrast application of the same 1 Hz LFS protocol completely reversed LTP induced by 3 × s400 Hz HFS in younger (2.5–3.5-month-old) TG animals (B). Left hand panels show LTP time course. Inserts show representative EPSP traces at the times indicated. Calibration bars: vertical, 1 mV; horizontal, 10 ms. Summary bar charts of potentiation at the same three time points (s200 Hz, last 10 min post-s200 Hz HFS; 3 × s400 Hz, last 10 min post-3 × s400 Hz HFS; 1 Hz, last 10 min post-1 Hz LFS) are in the right-hand panels. The # symbol stands for a statistical comparison with pre-HFS values within one group and the & symbol stands for a statistical comparison with pre-LFS values within one group (one-way ANOVA with repeated measures followed by post hoc Bonferroni test). An ^* indicates a comparison of potentiation values between groups (one-way ANOVA with post hoc Bonferroni test). One symbol, p < 0.05; two symbols, p < 0.01; three symbols, p < 0.001; ns, p > 0.05. Values are mean ± S.E.M.% pre-HFS baseline EPSP amplitude.