Figure 6.
ZIKV-induced IL-1β decreased the expression of aquaporins in renal cells. (A,B) Immunohistochemistry analysis of kidney sections showed comparable low immunoreactivity in the AQP1 and AQP2 labeling in both cortex and inner medulla (IM) of kidneys in newborn mice (A) and adult mice (B) at 7 days post-infection. The black arrows depicted AQP1and AQP2 expression. Scale bars, 40 μm. (C–H) The expression of AQP1 and AQP2 in the kidneys of newborn mice (C–E) and adult mice (F–H) were assessed by western blot at 7 days post-infection. The statistical graphs were shown as the mean ± SEM; N = 6 mice/group, *p < 0.05 vs. mock group; #p < 0.05 vs. ZIKV group.