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. 2019 Aug 20;9:12110. doi: 10.1038/s41598-019-47039-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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AIE-Induced Increase of Active Caspase-3 Immunoreactivity in the Dentate Gyrus is Reversed by Donepezil. Left Panel: Mean (+SEM) number of caspase-3 + IR positive cells/mm² in the granule cell layer of the dentate gyrus from dorsal hippocampus in rat brains exposed to AIE or AIW, and treated in adulthood with donepezil (filled bars) or the control vehicle (open bars). AIW/VEH n = 6, AIW/DZ n = 6, AIE/VEH n = 7, AIE/DZ n = 7 *p < 0.05 in post hoc analyses. Right Panels: Representative photomicrographs of caspase-3 + IR cells in the dentate gyrus of adult animals exposed to control vehicle in adolescence and in adulthood (AIW + Vehicle), AIE during adolescence and control vehicle in adulthood (AIE + Vehicle), control vehicle in adolescence and donepezil in adulthood (AIW + Donepezil), or AIE during adolescence and donepezil in adulthood (AIE + Donepezil). Arrows identify active caspase-3 + IR cells (Immunohistochemical staining, Bar scale = 25 μm).