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. 2018 Jun 21;84(6):E420–E429. doi: 10.1093/neuros/nyy279

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© Published by Oxford University Press on behalf of Congress of Neurological Surgeons 2017.

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FIGURE 4. — Fluoro-Jade C staining to show early neuronal degeneration. A, Fluro-Jade C stain imaging in the control animal (no muscimol infusion) demonstrated that the insertion of the microcatheter (white arrow) alone did not cause neuronal degeneration observable at ×100 magnification. B, Healthy, nondegenerating neurons can be seen near the tip of the microcatheter (white arrows) in the control animal (no muscimol infusion). One degenerating neuron may be present near the needle tract (black arrow)—magnification ×200. C, Fluoro-Jade C stain from a treatment NHP in the dose-escalation behavioral study who received a dose of muscimol with concentration of 4.4 mM. The needle tract (white arrow) is negative for neuron degeneration at ×100 magnification. D, One degenerating neuron (white arrow) was seen with the Fluoro-Jade C stain in a treatment animal receiving a dose of muscimol with concentration of 4.4 mM magnification ×400.