TABLE 1.

Behavioral Responses After Varying Concentrations of Muscimol Infusions

Animal	Experimental	Dose		VdMRI (mm3)	VdMRI (mm3)
no.	group	(mM)	Reaction	(right STN)	(left STN)	Histology
1	Early
		8.8	Alternating severe dyskinesia and somnolence	a	a	Predominantly normal, scattered neurons undergoing axonal regeneration
		88.8	Anesthetic coma requiring sacrifice
2	Early
		0.0625	Normal			Predominantly normal, scattered neurons undergoing axonal regeneration
		0.125	Normal	44.35	28.61
		0.25	Normal
		0.5	Normal
		1.1	Normal
		2.2	Mild dyskinesia
		4.4	Moderate dyskinesia
		8.8	Alternating severe dyskinesia & somnolence
3	Early
		0.125	Normal	43.64	35.44	Normal
		0.25	Normal
		0.5	Normal
		1.1	Mild dyskinesia
		2.2	Mild dyskinesia
		4.4	Moderate dyskinesia
4	Late
		0.125	Normal	26.40	21.65	Normal
		0.25	Normal
		0.5	Normal
		1.1	Mild dyskinesia
		2.2	Mild dyskinesia
		4.4	Severe dyskinesia
		8.8	Alternating severe dyskinesia and somnolence
		88.8	Anesthetic coma; survived without permanent side effects
5	Late
		0.0625	Normal			Normal
		0.125	Normal	49.25	41.73
		0.25	Mild dyskinesia
		0.5	Mild dyskinesia
		1.1	Mild dyskinesia
		2.2	Mild dyskinesia
		4.4	Moderate dyskinesia
		8.8	Alternating severe dyskinesia and somnolence
6	Late
		0.125	Normal	61.42	42.93	Normal
		0.25	Normal
		0.5	Normal
		1.1	Mild dyskinesia
		2.2	Mild dyskinesia
		4.4	Moderate dyskinesia

^aDistribution data from animal no. 1 was not obtained due to sacrifice of the animal before real-time MR-imaging of Gd-DTPA distribution.