Table 1.

Reported cases of pediatric SDS-related AML in the literature between 1994 and 2019.

Reference	Case	Age at diagnosis of AML (year)	AML FAB classification	Cytogenetics	Outcome
Donadieu et al. (2)	1	2.5	AML with MDS-related changes FAB M2	Monosomy 7 (no further details)	Death, no HSCT
	2	7.3	AML with MDS-related changes FAB M6	45,XY,del(5)(q?q?),add(9)(q?), +11,add(17)(p?), −20,+22	Death, HSCT complicated by viral infections
	3	6	AML with preceding MDS FAB M4	46,XY,add(7)(q31)[15]/46,XY [1].ish der(7)t(1;7)(q32;q31)	Death, no HSCT
Smith et al. (4)	4	11	AML with preceding MDS FAB M5	47,XY, 1,del(9)(q22)	Death
	5	4.5	AML with preceding MDS FAB M5	47, XY, der(7)t(4;7)(q31;q11),+21 [13]	Death
	6	8	AML with preceding MDS FAB M2	46,XY,add(11)(p?), −15, −22, +mar1, +mar2	Death
	7	6	AML with preceding MDS FAB M6	Not assessed	Death
Valli et al. (5)	8	13	AML with preceding MDS FAB NA	46,XY,der(6)t(3;6)(q26.3;q16.1)[13]	Alive, post HSCT
	9	9	AML with preceding MDS FAB NA	45,XX,der(7)t(7;18)(p11;?),-18 [7]/43,XX,der(5)t(5;6)(q?28;q?13),der(6)t(6;13)(q21;q?),del(6)(q?13), der(7)t(7;18)(p11;?),−13,der(15)t((del(15)(q22);22)(p11.2;p11.2),−18 [14]	Death

SDS, Shwachman-Diamond; AML, acute myeloid leukemia; MDS, myelodysplastic syndrome; HSCT, hematopoietic stem cell transplant; FAB, French-American-British classification of AML; NA, not available; ?, questionable identification of a chromosome or chromosome structure.