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. 2019 Aug 14;10:1930. doi: 10.3389/fimmu.2019.01930

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Copyright © 2019 Xu, Wang, Guo, Bai, He, Wang, Lin, Fisher, Liu and Yao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of PTP1B promotes MKP1 via decreasing miR-26a production. (A) miRNAs expression profiles analysis. Ptpn1 WT cells and knockdown cells were incubated for 24 h and then harvested for deep-sequencing analysis. Three independent experiments were performed and fold changes (in log2 value) of control group are listed in heatmap. (B) The expression of MKP1 is regulated by miR-26a. Cells were treated by miR-26a mimic or miR-26a inhibitor for 24 h respectively, and harvested for Western blot detection. Data are expressed as mean ± SD of three independent experiments. **p < 0.01 indicates statistically significant differences as compared with the control group.