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. 2019 Aug 14;10:1930. doi: 10.3389/fimmu.2019.01930

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Copyright © 2019 Xu, Wang, Guo, Bai, He, Wang, Lin, Fisher, Liu and Yao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PUN treatment prevents sepsis-induced excessive inflammation in mice. (A) Kaplan–Meier curves for the survival rate of septic mice. Eighty mice were involved in the comparison. The dosages of PUN used in this study were indicated as 0, 10, and 20 mg/kg·bw, respectively. PUN was orally administrated at the indicated dosage 3 days ahead of CLP surgery. Then all mice had surgery with or without cecal ligation and puncture. The observation for mortality continued for 7 days. (B) ELISA detection on expression of serum cytokines (24 h after surgery). Data are expressed as mean ± SD of three independent experiments. *p < 0.05 indicates statistically significant differences as compared with the CLP surgery group. **p < 0.01 indicates statistically significant differences compared with LPS group.