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. 2019 Aug 14;9:780. doi: 10.3389/fonc.2019.00780

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Copyright © 2019 Mitchell, Chintala, Fetcko, Henriquez, Tewari, Ahmed, Bentley and Dey.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Top 10 upregulated genes in canine oligodendroglioma. (A) Expression of the top 10 upregulated genes in canine glioma cases based on RNAseq data. (B) qPCR/RT-PCR analysis confirming the upregulation of the top 10 upregulated genes in canine ODG (9 genes; 10th gene by IHC/WB). Figure 9 compared to normal brain (C) expression of the top 10 upregulated genes in human glioma subtypes: Glioblastoma (GBM), Oligodendroglioma (ODG), Oligoastrocytoma (OA), and Anaplastic Astrocytoma (AA), based on data from Xena Browser (TCGA: low grade glioma and glioblastoma). CENPU expression was not available in human data and was, therefore, excluded from this dataset (*p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001) (D) comparison of the suggested protein associations between the protein products of the top 10 upregulated genes between humans and canines. Data was based on reported associations from the STRING database (functional protein association network version-10-5). Medium confidence (0.400) was used for human patients, whereas low confidence (0.150) was required for the canine data due to lack of supporting data. Red nodes indicate proteins involved in similar interactions in humans and canines.