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. 2019 Aug 14;9:780. doi: 10.3389/fonc.2019.00780

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Copyright © 2019 Mitchell, Chintala, Fetcko, Henriquez, Tewari, Ahmed, Bentley and Dey.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of the suggested protein associations of the top 10 downregulated genes. Data was collected using the STRING database (functional protein association network version-10-5) at medium confidence (0.400). Increasing confidence is demonstrated by increased thickness and darkness of edges (intersecting lines). Red notes indicate proteins involved in similar associations in both humans and canines. Light Blue nodes indicate proteins that are members of the top 10 CD category. Dark blue nodes indicate proteins that are members (other than the CD gene being evaluated) of the CD gene category.