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. 2019 Aug 14;9:780. doi: 10.3389/fonc.2019.00780

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Copyright © 2019 Mitchell, Chintala, Fetcko, Henriquez, Tewari, Ahmed, Bentley and Dey.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overexpression of cell cycle regulators KIF-11 and UBE2C in human and canine glioma. (A) Overexpression of KIF-11 mRNA (TCGA data) in human GBM, ODG, OA, and AA tumors. (B) KIF-11 protein levels were upregulated in human GBM (Human Protein Atlas). (C) Western blot analysis showed the overexpression of KIF-11 in canine ODG compared to normal brain. (D) UBE2C mRNA overexpression (TCGA data) in human GBM, ODG, OA, and AA tumors. (E) UBE2C protein levels were overexpressed in human GBM (Human Protein Atlas). (F) Western blot analysis showed the overexpression of UBE2C in canine ODG as compared to normal brain. (G) IHC analysis of KIF-11 and UBE2C in canine ODG cases (n = 10). Specific staining intensity was classified as high with strong signal with 100% cells positivity and medium as moderate to strong signal with 60–80 percent cells positivity. Quantification of high and medium expression cases were performed and presented as percent cases.