Table 3.
Risk stratification by time-weighted BP and time-weighted HbA1c for predicting CAD risk in individuals with childhood-onset type 1 diabetes
| Model 1 |
Model 2 |
|||
|---|---|---|---|---|
| HR (95% CI) |
P value | HR (95% CI) | P value | |
| SBP/DBP | ||||
| BP ≥120/80 vs. <120/80 mmHg | 2.4 (1.8, 3.3) | <0.001 | 1.9 (1.4, 2.6) | <0.001 |
| BP <120/80 mmHg and HbA1c <8% | Reference | Reference | ||
| BP ≥120/80 mmHg and HbA1c <8% | 2.3 (1.3, 4.3) | 0.007 | 2.0 (1.06, 3.9) | 0.033 |
| BP <120/80 mmHg and HbA1c ≥8% | 2.2 (1.4, 3.6) | 0.002 | 1.6 (0.97, 2.8) | 0.071 |
| BP ≥120/80 mmHg and HbA1c ≥8% | 5.8 (3.5, 9.7) | <0.001 | 3.3 (1.9, 6.0) | <0.001 |
| MAP | ||||
| MAP ≥90 vs. <90 mmHg | 3.5 (2.6, 4.7) | <0.001 | 2.6 (1.6, 3.5) | <0.001 |
| MAP <90 mmHg and HbA1c <8% | Reference | Reference | ||
| MAP ≥90 mmHg and HbA1c <8% | 4.6 (2.5, 8.4) | <0.001 | 3.4 (1.8, 6.5) | <0.001 |
| MAP <90 mmHg and HbA1c ≥8% | 2.6 (1.6, 4.2) | <0.001 | 1.9 (1.1, 3.2) | 0.016 |
| MAP ≥90 mmHg and HbA1c ≥8% | 8.5 (5.1, 14.1) | <0.001 | 4.9 (2.7, 8.7) | <0.001 |
Model 1 was adjusted for age, sex, diabetes duration, and current use of antihypertensive medications. Model 2 was adjusted for the model 1 variables plus ever smoking; updated mean BMI, HDL cholesterol, and non–HDL cholesterol; and raised albuminuria.