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. 2019 Jun 14;68(9):1806–1818. doi: 10.2337/db19-0349

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© 2019 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.

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Swi/Snf affects a broad range of metabolic processes in islet β-cells. A: Top, volcano plot shows the most differentially expressed genes in βDKO β-cells. Bottom: The most significant biological pathways identified by gene ontology (GO) analysis. Swi/Snf contributed to very divergent regulatory processes, varying from cell adhesion (most significant) to ion transport, cell migration, and carbohydrate metabolism (least significant). Expression of Swi/Snf subunits BAF250A (Arid1a), BAF53B (Actl6b), and BAF60C (Smarcd3) was increased in βDKO β-cells by 2.11-, 2.08-, and 10.3-fold, respectively. FDR, false discovery rate. B: qPCR analysis from FACS-purified Tomato⁺ β-cells of various βDKO genes upregulated in the RNA sequencing. n = 3. *P < 0.05; **P < 0.01.