Table 4.
Association between the IC biomarkers and the risk of MI events in unadjusted, minimally adjusted, and final adjusted Cox models
| Unadjusted |
Adjusted for age and HbA1c |
Final models* |
||||
|---|---|---|---|---|---|---|
| HR (95% CI)** | P value | HR (95% CI)** | P value | HR (95% CI)** | P value | |
| DCCT baseline (36 events, n = 518) | ||||||
| AGE-LDL-IC (mg/L) | 1.53 (1.12, 2.11) | 0.008 | 1.48 (1.07, 2.04) | 0.018 | 1.42 (1.02, 1.99) | 0.040 |
| MDA-LDL-IC (mg/L) | 1.35 (1.04, 1.76) | 0.027 | 1.36 (1.02, 1.80) | 0.035 | 1.32 (0.98, 1.77) | 0.069 |
| oxLDL-IC (mg/L) | 1.94 (1.33, 2.83) | 0.001 | 1.86 (1.27, 2.72) | 0.001 | 1.75 (1.18, 2.58) | 0.005 |
| DCCT closeout (33 events, n = 504) | ||||||
| AGE-LDL-IC (mg/L) | 1.47 (1.04, 2.07) | 0.028 | 1.40 (0.99, 2.00) | 0.061 | 1.27 (0.88, 1.83) | 0.210 |
| MDA-LDL-IC (mg/L) | 1.40 (1.06, 1.86) | 0.019 | 1.40 (1.03, 1.90) | 0.034 | 1.26 (0.92, 1.71) | 0.150 |
| oxLDL-IC (mg/L) | 1.97 (1.31, 2.95) | 0.001 | 1.83 (1.21, 2.75) | 0.004 | 1.65 (1.09, 2.49) | 0.018 |
| All measurements (36 events, n = 518) | ||||||
| AGE-LDL-IC (mg/L) | 1.45 (1.03, 2.05) | 0.035 | 1.34 (0.94, 1.92) | 0.113 | 1.26 (0.87, 1.81) | 0.223 |
| MDA-LDL-IC (mg/L) | 1.34 (0.97, 1.84) | 0.073 | 1.28 (0.92, 1.77) | 0.146 | 1.20 (0.87, 1.64) | 0.263 |
| oxLDL-IC (mg/L) | 1.77 (1.16, 2.70) | 0.008 | 1.56 (1.03, 2.36) | 0.038 | 1.45 (0.96, 2.19) | 0.079 |
P values <0.05 are presented in boldface type.
*Adjusted for age, mean HbA1c, mean LDL, and (log) AER. The number of covariates was reduced in the final models due to the small number of events (see research design and methods).
**Per 1 unit increase in the log-transformed biomarker value. The HR per (for example) a 25% increase in the biomarker (or, equivalently, a 1.25-fold change) is given by HR^log(1.25), where “^” denotes “to the power of.” Biomarkers are noted amount per milligram of apoB contained in the IC, using serum total apoB/L.