Table 4.
Host genetic factors associated with response to hepatitis B vaccine.
| Category | Gene ontology | Gene | Genetic determinants (SNP/Hap/CNVs) | Main reference |
|---|---|---|---|---|
| I | HLA | HLA-DP | rs9277535 | Png et al., 2011; Wu et al., 2015b |
| HLA-DQB1 | *02, *05, *0501, *06, *0602 | Li et al., 2013b; Nishida et al., 2018 | ||
| HLA-DRB1 | *01, *03, *0301, *04, *07, *1301, *1302,*15 | Li et al., 2013b; Yoon et al., 2014; Nishida et al., 2018 | ||
| Cytokines | IL-4 | rs2070874, rs2227284, rs2243250 | Wang et al., 2012; Cui et al., 2013 | |
| II | HLA | HLA-B | *62 | Yoon et al., 2014; Roh et al., 2016 |
| HLA-DP | rs2116260, rs3128961, rs35953215, rs3830066, rs4282438, rs5025825, rs6457709, rs7770370, rs9277542, *04:02, *05:01, *09:01, *02:02, *03:01:01, *04:01:01, A-G-A-G-G1, A-G2, A-G-A-G-G-A-G3 | Wu et al., 2015b; Sakai et al., 2017; Nishida et al., 2018 | ||
| HLA-DQB1 | *0401 | Xu et al., 2017a; Nishida et al., 2018 | ||
| HLA-DR | rs3135363 | Png et al., 2011 | ||
| HLA-DRA | rs7192, rs2395177, rs5000563 | Davila et al., 2010 | ||
| HLA-DRB1 | *01:01, *04:05, *08, *08:03, *15:01, rs477515, rs13204672, rs28366298 | Sakai et al., 2017; Nishida et al., 2018 | ||
| HLA-DRB1-DQB1 | *01:01-*05:01,*04:05-*04:01,*08:03-*06:01,*14:06-*03:01, *15:01-*06:02 | Nishida et al., 2018 | ||
| HLA-III | rs9267665 | Png et al., 2011 | ||
| Others | BTNL2 | rs2076530, rs3763311, rs3763313, rs3763316, rs3806156, rs3817963, rs4248166, rs9268494, rs9268501, A-A4, C-G5, G-T-A-T-C-A-G6, G-T-A-T-C7, G-C-A-T-C8 | Davila et al., 2010; Pan et al., 2014; Yang et al., 2014; Nishida et al., 2018 | |
| FOXP1 | rs6789153 | Davila et al., 2010 | ||
| LILRB4 | rs1654668 | Davila et al., 2010 |
Haplotypes
1A-G-A-G-G, rs5025825-rs6457709-rs35953215-rs3830066-rs7770370; 2A-G, rs3128961-rs9277535; 3A-G-A-G-G-A-G, rs5025825-rs6457709-rs35953215-rs3830066-rs7770370-rs3128961-rs9277535; 4A-A, rs3806156-rs2076530; 5C-G, rs3806156-rs2076530; 6G-T-A-T-C-A-G, rs9268501-rs3763316- rs3763313-rs3763311- rs9268494- rs3806156-rs2076530; 7G-T-A-T-C, rs9268501-rs3763316- rs3763313-rs3763311-rs9268494; 8G-C-A-T-C, rs9268501-rs3763316- rs3763313-rs3763311-rs9268494.