Table 3.
Comparison between complicated and non-complicated pregnancies: univariate and multivariate analysis.
| Complicated pregnancies (n = 8) | Non-complicated pregnancies (n = 54) | p-value (univariate analysis) | |
|---|---|---|---|
| Age (mean ± SD) | 28.3 ± 5.8 | 32.4 ± 4.8 | 0.028§ |
| Nulliparity | 6/8 (75.0%) | 43/54 (79.6%) | 0.670 |
| Acquired risk factorsa | 6/8 (75.0%) | 13/54 (24.1%) | 0.008§ |
| Inherited thrombophiliab | 2/8 (25.0%) | 3/28 (10.7%) | 0.305 |
| Autoimmune thyroiditis | 2/8 (25.0%) | 11/54 (20.4%) | 0.670 |
| Non-criteria APS manifestationsc | 3/8 (37.5%) | 3/54 (5.6%) | 0.024§ |
| Lupus-like manifestationsd | 3/8 (37.5%) | 2/54 (3.7%) | 0.013§ |
| Single aPL positivity | 3/8 (37.5%) | 37/54 (68.5%) | 0.119 |
| LAC | 0/3 (0%) | 0/37 (0%) | |
| aCL IgG/IgM | 3/3 (100%) | 13/37 (35.1%) | |
| aB2GPI IgG/IgM | 0/3 (0%) | 24/37 (64.9%) | |
| Double aPL positivity | 0/8 (0%) | 13/54 (24.1%) | 0.186 |
| aCL + LAC | 0/0 (0%) | 1/12 (7.7%) | |
| aCL + aB2GPI | 0/0 (0%) | 12/13 (92.3%) | |
| Triple aPL positivity | 5/8 (62.5%) | 4/54 (7.4%) | 0.001§* |
| No treatment | 1/8 (12.5%) | 19/54 (35.2%) | 0.258 |
| LDAe | 3/8 (37.5%) | 31/54 (57.4%) | 0.450 |
| LDA+LMWHf | 4/8 (50.0%) | 4/54 (7.4%) | 0.007 |
Acquired risk factors: obesity; current smoke; any previous diagnosis of diabetes mellitus, dyslipidemia, systemic arterial hypertension.
Inherited thrombophilia: antithrombin or protein C or protein S deficiency, homozygous factor V Leiden or prothrombin or methylenetetrahydrofolate reductase (MTHFR) mutation.
Non-criteria aPL manifestations: superficial venous thrombosis, thrombocytopenia, microangiopathy, heart valve disease, livedo reticularis, migraine, chorea, seizures and myelitis.
Lupus-like manifestations: arthralgia, Raynaud's phenomenon, photosensitivity, alopecia.
LDA, low dose aspirin.
LMWH, low molecular weight heparin.
Variables considered at the multivariate analysis;
p-value (multivariate analysis): 0.01, OR (95% CI): 21.3 (1.84–247).