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. 2019 Aug 7;2019:5020465. doi: 10.1155/2019/5020465

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Copyright © 2019 Lawrence Coppey et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effect of late intervention with dietary oils on vascular relaxation by calcitonin gene-related peptide in epineurial arterioles of the sciatic nerve in high-fat-fed diabetic Sprague-Dawley rats. Pressurized arterioles (40 mm Hg and ranging from 60 to 100 μm luminal diameters) were constricted with phenylephrine (30-50%), and incremental doses of calcitonin gene-related peptide were added to the bathing solution while recording the steady-state vessel diameter. Data are presented as the mean of % relaxation ± SEM. The number of rats in each group was the same as shown in Table 2. Using area under the curve to compare the effect of diabetes and treatments to relaxation by calcitonin gene-related peptide: control vs. diabetic, P < 0.05; control vs. diabetic+OO, P < 0.05; control vs. diabetic+SO, P < 0.05; diabetic vs. diabetic+MO, P < 0.05. OO: olive oil; SO: safflower oil; EPO: evening primrose oil; FO: flaxseed oil; MO: menhaden oil.