Table 2.
Effect of dietary oils on weight gain, serum lipids, and thiobarbituric acid substances and liver steatosis in type 2 diabetic Sprague-Dawley rats: late intervention.
Determination | Control (10) | Diabetic (12) | Diabetic+olive oil (12) | Diabetic+safflower oil (12) | Diabetic+evening primrose oil (12) | Diabetic+flaxseed oil (12) | Diabetic+menhaden oil (12) |
---|---|---|---|---|---|---|---|
Start weight (g) | 346 ± 5 | 358 ± 3 | 347 ± 6 | 352 ± 4 | 349 ± 3 | 340 ± 6 | 352 ± 6 |
End weight (g) | 547 ± 21 | 496 ± 19 | 506 ± 21 | 496 ± 15 | 498 ± 21 | 514 ± 21 | 520 ± 20 |
Blood glucose (mg/dl) | 126 ± 4 | 438 ± 48a | 431 ± 46a | 389 ± 46a | 447 ± 46a | 361 ± 47a | 424 ± 48a |
Serum free fatty acid (mmol/l) | 0.13 ± 0.01 | 0.44 ± 0.08a | 0.52 ± 0.04a | 0.54 ± 0.14a | 0.36 ± 0.08a | 0.41 ± 0.05a | 0.60 ± 0.07a |
Serum triglycerides (mg/dl) | 47 ± 12 | 773 ± 176a | 1248 ± 270a | 613 ± 191a | 394 ± 49a | 536 ± 134a | 829 ± 156a |
Serum cholesterol (mg/ml) | 4.7 ± 0.5 | 9.4 ± 1.3a | 8.9 ± 1.5a | 12.6 ± 1.5a | 7.6 ± 1.0 | 7.4 ± 0.6 | 8.6 ± 0.9a |
Serum thiobarbituric acid substances (μg/ml) | 0.42 ± 0.04 | 1.20 ± 0.13a | 1.15 ± 0.09a | 1.13 ± 0.13a | 1.12 ± 0.08a | 1.25 ± 0.13a | 1.25 ± 0.14a |
Liver steatosis (%) | 5.8 ± 0.4 | 44.4 ± 1.2a | 36.2 ± 1.2a,b | 34.1 ± 1.1a,b | 35.4 ± 1.2a,b | 33.5 ± 1.5a,b | 31.8 ± 1.4a,b |
Data are presented as the mean ± SEM. a P < 0.05 compared to control rats. b P < 0.05 compared to diabetic rats. Parentheses indicate the number of experimental animals.