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. 2019 May 24;9:25. doi: 10.25259/JCIS-18-2019

Figure 9.

Figure 9

Temporal evolution of different cases of Krabbe disease on serial magnetic resonance imaging (MRI). A 6-year-old boy with Juvenile Krabbe (a-d) - initial fluid-attenuated inversion recovery (FLAIR) axial image (a) shows confluent posterior periventricular and splenial hyperintensity (white arrow). T2 axial (b), FLAIR axial (c), and diffusion-weighted imaging (DWI) (d) images from subsequent MRI done after 3 years show asymmetric CST involvement with bilateral restricted diffusion(arrows). A 14-year-old boy who presented initially with right hemiparesis which progressed to spastic quadriparesis over a 3-year period. Serial MRI (e-h) shows initial DWI with mild left CST restricted diffusion. Subsequent MRI (f) shows a new area of restricted diffusion along right CST. T2 axial (g) acquired at the same time shows chronic changes on the left side and more acute changes on the right. Later, MRI shows bilateral chronic changes along CST (h). Serial MRI (i-l) of a 5-year-old girl from juvenile group shows patchy scattered white matter changes on initial FLAIR axial image (i) progressing to confluent involvement with tigroid pattern in a subsequent MRI done after 34 months (k). Both scans (j, l) show dentate hilum involvement with sparing of deep cerebellar white matter.