Figure 1.

Depiction of the BrainAGE concept. All MRI data are automatically preprocessed via VBM. (A) The model of healthy brain aging is trained with the chronological age and preprocessed structural MRI data of a training sample (left; with an illustration of the most important voxel locations that were used by the age regression model). Subsequently, the individual brain ages of previously unseen test subjects are estimated, based on their MRI data. (B) The difference between the estimated and chronological age results in the BrainAGE score, with positive BrainAGE scores indicating advanced brain aging (orange line), increasing BrainAGE scores indicating accelerating brain aging (red line), and negative BrainAGE scores indicating delayed brain aging (green line). [Figure and legend adapted from Franke et al. (45), with permission from Hogrefe Publishing, Bern].