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. 2019 Aug 14;10:789. doi: 10.3389/fneur.2019.00789

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Copyright © 2019 Franke and Gaser.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Longitudinal BrainAGE in APOE ε4-carriers and ε4-non-carriers. BrainAGE scores at (A) baseline for APOE ε4-carriers [C] and non-carriers [NC] in the 4 diagnostic groups NO, sMCI, pMCI, and AD. BrainAGE scores differed significantly between diagnostic groups (p < 0.001). Post-hoc tests showed significant differences between BrainAGE scores in NO as well as sMCI from BrainAGE scores in pMCI as well as AD (p < 0.05). (B) Estimated longitudinal changes in BrainAGE scores for the 4 diagnostic groups: NO (light blue), sMCI (green), pMCI (red) and AD (blue), subdivided into APOE ε4 carriers and non-carriers. Post-hoc t-tests resulted in significant differences for ε4 carriers and non-carriers as well as for NO/sMCI vs. pMCI/AD (p < 0.05). [Figures and legend reproduced from Loewe et al. (36), permitted under the Creative Commons Attribution License].