Figure 6.

Anti-tumor efficacy of class II HER2 peptides pulsed DC1 in combination with anti-PD-1 antibody therapy. (A) Balb/C mice were injected with 2.5 × 10⁵ TUBO cells subcutaneously on the right flank on day 0. When tumors were palpable on day 7, mice received class II HER2 peptides pulsed DC1 vaccine (1 × 10⁶ DC1/mouse/100 μl) subcutaneously on the left flank twice a week for a total of six doses followed by intraperitoneal injection of 150 μg/mouse/200 μl of anti-PD-1 antibody twice a week until the end point. (B) Survival curve. Data shown are representative from three independent experiments and are shown as the mean number ± SEM. P-values were determined by unpaired student t-test (A) or a log-rank test (B). ***p < 0.001, **p < 0.01.