Table 2.
Targeting strategies for AuNPs toward TME.
| System name | Nanoparticle (type) | TME component | Diagnostics | Therapeutics | 3D in vitro/in vivo model | References |
|---|---|---|---|---|---|---|
| “Smart” AuNPs (SANs) | AuNP | Acidic pH | PAI | Xenograft mouse model | Song et al., 2016 | |
| c(RGDyK)-MHDA/LSC@AuNP | AuNP | Acidic pH | PAI | Xenograft mouse model | Li et al., 2019 | |
| LGAuNP | AuNP | Acidic pH | FLimaging | Xenograft mouse model | Lai et al., 2017 | |
| GNPs-CKL-FA | AuNP | Acidic pH | FLimaging | Xenograft bearing mice model | Tang et al., 2019 | |
| AuNR@ MSN-RLA/CS(DMA)-PEG | AuNR | Acidic pH | PDT; PTT |
Xenograft bearing mice model | Liu et al., 2018b | |
| DOX-EGF-SA-AuNP | AuNP | Acidic pH | DD | Xenograft mouse model | Feng et al., 2017 | |
| MC-GNPs | AuNP | Acidic pH | PTT | Li et al., 2014 | ||
| pH-GSNPs | Gold Shell nanoparticles | Acidic pH | PTT; DD | Dai et al., 2015 | ||
| MBA/SMART-AuNP | AuNP | Acidic pH | SERS imaging | PTT | Jung et al., 2013 | |
| Gold nanomachines | AuNP | Acidic pH | PAI | PTT | Xenograft mouse model | Yu et al., 2017 |
| AuNC@MnO2 | AuNC | Acidic pH; Hypoxia; Immunosuppressive tumor microenvironment |
FL imaging; PAI; MRI |
PDT | Xenograft mouse model | Liang et al., 2018 |
| V7-CMG | AuNR | Acidic pH | MSOT | DD | Xenograft mouse model | Zeiderman et al., 2016 |
| Nanoprobe | AuNP | MMP-2; MMP-7 | FLimaging | Wang et al., 2012 | ||
| MMP-sensitive AuNP probe | AuNP | MMP | NIRF tomographic imaging | Xenograft mouse model | Lee et al., 2008 | |
| MMP-GC-AuNPs | AuNP | MMP | CT; FLimaging |
Xenograft bearing mice model | Sun et al., 2011 | |
| G-AuNPs-DOX-PEG | AuNP | MMP-2 Acidic pH |
DD | Xenograft bearing mice model | Ruan et al., 2015a | |
| DOX-GLT/EGCG AuNPs | AuNP | MMP | FLimaging | DD | Tsai et al., 2016 | |
| G-AuNPs-DC-RRGD | AuNP | MMP-2; Acidic pH |
FLimaging | DD | Xenograft bearing mice model; Spheroid |
Ruan et al., 2015b |
| DOX-substrate/AuNP | AuNP | MMP-2 | FLimaging | DD | Xenograft bearing mice model | Chen et al., 2013 |
| CDGM NPs | GNC | MMP-2; Acidic pH |
FLimaging | PDT; DD |
Xenograft bearing mice model | Xia et al., 2018 |
| Au@BSA-NHA | AuNP | Hypoxia | CT | Xenograft bearing mice model | Shi et al., 2016 | |
| Au-PCM-AIDH | AuNC | Hypoxia | PTT; Free Radicals | Shen et al., 2017 | ||
| DOX-HZN-DTDP @ Au NPs-LA-PEG2000-CAI | AuNP | Hypoxia Acidic pH |
DD | Spheroid | Shabana et al., 2018 |
AuNP, spherical gold nanoparticles; AuNR, gold nanorods; AuNC, gold nanocages; SERS imaging, Surface-enhanced Raman scattering imaging; PTT, photothermal therapy; FLimaging, Fluorescence imaging; MRI, magnetic resonance imaging; PAI, photoacoustic imaging, PDT, photodynamic therapy; MMP, matrix metalloproteinases; MMP-2, matrix metalloproteinases; NIRF tomografic imaging, near infrared fluorescence imaging; CT, computed tomography; DD, drug delivery; DOX, doxorubicin; PCM, phase-change material.