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. 2019 Aug 14;6:116. doi: 10.3389/fcvm.2019.00116

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Copyright © 2019 Iwabu, Okada-Iwabu, Yamauchi and Kadowaki.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The roles of decreased adiponectin/AdipoR effects in obesity-related diseases and potential strategies to increase the effects of AdipoR. Decreased adiponectin/AdipoR effects play causal roles in obesity-related diseases. Increased activation of AdipoR pathways may have beneficial effects on healthy longevity and obesity-related diseases, such as metabolic syndrome, type 2 diabetes, cardiovascular diseases, cancers, and Alzheimer's disease.