Burford 2013.

Methods	Randomised controlled trial Location: Perth, Australia. Funding: No information provided Recruitment: Participants were recruited from 8 metropolitan community pharmacies around Perth city centre, Western Australia, when presenting to collect prescribed medications or over‐the‐counter medications. No incentive was offered for participation. The study was conducted between January 2010 and December 2010.
Participants	Participants (n = 160) (Intervention n = 80; control n = 80) were aged between 18 and 30 years, smokers (defined as smoking 1+ CPD by self‐report); able to give consent; available for follow‐up at 6 months; no beards, moustaches, or non‐removable facial accessories; no body dysmorphia; and not using NRT or taking oral drugs for nicotine dependence. No overall baseline characteristics provided, and trial arms were balanced on all recorded characteristics
Interventions	The face simulation software intervention was a tailored and interactive Internet‐based intervention as an adjunct to behavioural intervention, and was delivered over 1 brief session. In the intervention arm an Internet‐based 3‐dimensional age progression software package created a stream of aged images of faces from a standard digital photograph; the resulting aged image was adjusted to compare how the participant aged as a smoker versus as a non‐smoker. Participants also received standard 2‐minute smoking cessation advice from the pharmacist. The control arm was a brief face‐to‐face non‐internet‐based, non‐active control arm in which participants received standard 2‐minute smoking cessation advice from the pharmacist
Outcomes	Outcome data were collected at 1, 3, and 6 months. Outcomes were: bioverified (48 hours of follow‐up survey) PPA, quit attempts, transtheoretical stages of change, nicotine dependence, cost effectiveness of the intervention, and viability of delivering the intervention in a community pharmacy
Notes	Cost of implementing the intervention was AUD 463, or the equivalent of AUD 5.79 per participant. The incremental cost‐effectiveness ratio was AUD 46 per additional quitter, or the equivalent of AUD 74 per additional lifetime quitter. Authors reported no conflicts of interest
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	High risk	Participants were recruited and assigned by the researcher to the different arms of the study on alternate weeks
Allocation concealment (selection bias)	High risk	Participants were recruited and assigned by the researcher to the different arms of the study on alternate weeks
Incomplete outcome data (attrition bias) All outcomes	Low risk	Attrition rates: 26% intervention; 21% control