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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Trends Cancer. 2019 Jul 20;5(8):495–505. doi: 10.1016/j.trecan.2019.06.003

Figure 2. The blood-tumor barrier has altered anatomy and physiology.

Figure 2.

Cancer cells coopt the cerebral vasculature and induce neo-angiogenesis resulting in fenestrated endothelia lacking tight junctional expression. Fenestrated, mal-formed vasculature allows for heterogeneous uptake of drug solutes. Cancer cells have increased expression of the P-gp and BCRP efflux transporters. At the BTB, less astrocytic end-foot processes and pericytes exist contributing to altered BTB integrity.