Figure 6.

Time course of changes in heat sensitivity in whisker pad skin of CFA-injected or saline-injected mice after administration of the TRPV1 antagonist SB366791. Head withdrawal latency increased after administration of SB366791 in CFA-injected mice, but not in saline-injected. Head withdrawal latency was measured from 0 to 90 min after SB366791 administration. Data are expressed as percentage (mean ± SEM) for head withdrawal latency for each animal, normalized to head withdrawal latency (100%) on preadministration. *p < 0.05 compared with head withdrawal latency before administration of SB366791 (n = 5 in each group; two-way ANOVA with repeated measures followed by Bonferroni's multiple-comparison tests).